WARFARIN ANTIDOTE SKIN

Intensity of anticoagulation for the indicated conditions. Consult the latest evidence-based clinical practice guidelines regarding the duration and Adjust the dose based on the patient’s INR and the condition being The dosage and administration of COUMADIN must be individualized for each patient according to the Sodium hydroxide, as needed for pH adjustment to 8.1 to 8.3ĭOSAGE AND ADMINISTRATION Individualized Dosing It is very soluble in water, freely soluble in alcohol, and very slightly soluble in chloroform and ether.ĬOUMADIN tablets for oral use also contain:ĬOUMADIN for injection for intravenous use is supplied as a sterile, lyophilized powder, which, after reconstitution with 2.7 mL Sterile Water for Injection, contains: Its empirical formula is C 19H 15NaO 4, and its structural formula is represented by the following:Ĭrystalline warfarin sodium occurs as a white, odorless, crystalline powder that is discolored by light. Crystalline warfarin sodium is an isopropanol clathrate. The chemical name of warfarin sodium is 3-(α-acetonylbenzyl)-4-hydroxycoumarin sodium salt, which is a racemic mixture of the R- and S-enantiomers. ĬOUMADIN (warfarin sodium) tablets and COUMADIN (warfarin sodium) for injection contain warfarin sodium, an anticoagulant that acts by inhibiting vitamin K⌈dependent coagulation factors. Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding.Drugs, dietary changes, and other factors affect INR levels achieved with COUMADIN therapy.Perform regular monitoring of INR in all treated patients.COUMADIN can cause major or fatal bleeding.You may report side effects to FDA at 1-80. Call your doctor for medical advice about side effects. For more information, ask your healthcare provider or pharmacist. These are not all of the side effects of Coumadin. “Purple toes syndrome.” Call your healthcare provider right away if you have pain in your toes and they look purple in color or dark in color.

Tell your healthcare provider right away if develop blood in your urine.Your healthcare provider may do tests more often during treatment with Coumadin to check for bleeding if you already have kidney problems. Kidney injury may happen in people who take Coumadin. You may need medical care right away to prevent death or loss ( amputation) of your affected body part. Call your healthcare provider right away if you have pain, color, or temperature change to any area of your body. It happens because blood clots form and block blood flow to an area of your body. This can happen soon after starting Coumadin.

WARFARIN ANTIDOTE SKIN

Death of skin tissue (skin necros is or gangrene).

Blood clots can cause a stroke, heart attack, or other serious conditions if they form in the legs or lungs.Ĭoumadin may cause serious side effects including: Coumadin is prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your body.